APA
Click to copy
Taylor, S. R., Olson, C., Ripoll-Sánchez, L., Valperga, G., McWhirter, R. M., Barney, S. T., … Miller, D. M. (2025). A gene expression atlas of a juvenile nervous system. BioRxiv.
Chicago/Turabian
Click to copy
Taylor, Seth R., Claire Olson, Lidia Ripoll-Sánchez, Giulio Valperga, Rebecca M. McWhirter, S. T. Barney, Alexander Atkinson, et al. “A Gene Expression Atlas of a Juvenile Nervous System.” bioRxiv (2025).
MLA
Click to copy
Taylor, Seth R., et al. “A Gene Expression Atlas of a Juvenile Nervous System.” BioRxiv, 2025.
BibTeX Click to copy
@article{seth2025a,
title = {A gene expression atlas of a juvenile nervous system},
year = {2025},
journal = {bioRxiv},
author = {Taylor, Seth R. and Olson, Claire and Ripoll-Sánchez, Lidia and Valperga, Giulio and McWhirter, Rebecca M. and Barney, S. T. and Atkinson, Alexander and Goel, Sidharth and Weinreb, Alexis and Hardin, Andrew and Rolfson, Alexis and Pattee, Jacob and Aguilar, G. R. and Merritt, Daniel M and Eroglu, Matthew and Majeed, Maryam and Grundvig, Ethan and Child, Ethan and Beets, Isabel and Vértes, P. and Schafer, WR and Varol, E. and Hammarlund, Marc and Hobert, Oliver and Miller, David M.}
}
Although the fundamental architecture of metazoan nervous systems is typically established in the embryo, substantial numbers of neurons are added during post-natal development while existing neurons expand in size, refine connectivity, and undergo additional differentiation. To reveal the underlying molecular determinants of post-embryonic neurogenesis and maturation, we have produced gene expression profiles of all neuron types and their progenitors in the first larval stage (L1) of C. elegans. Comparisons of the L1 profile to the embryo and to the later L4 larval stage identified thousands of differentially expressed genes across individual neurons throughout the nervous system. Key neuropeptide signaling networks, for example, are remodeled during larval development. Gene regulatory network analysis revealed potential transcription factors driving the temporal changes in gene expression across the nervous system, including a broad role for the heterochronic gene lin-14. We utilized available connectomic data of juvenile animals in combination with our neuron-specific atlas to identify potential molecular determinants of membrane contact and synaptic connectivity. These expression data are available through a user-friendly interface at CeNGEN.org for independent investigations of the maturation, connectivity and function of a developing nervous system.